Abstract: Cultural confidence is the root of the survival and development of Chinese nation. Under the background of the globalization and the integration of different cultures, cultural confidence means to possess an international perspective and Chinese esthetic perception. Based on a comparison between Chinese literature and American literature, between English literature and American literature, and a historical comparative perspective of American literature, the integral optimization and reform of the course content of American Literature will help broaden students' international view, elevate their cultural confidence, promote their national pride and possess Chinese esthetic perception.