Abstract: The open economy with foreign trade as its important content is still the short slab of economic development in Anhui Province. In the new era, Anhui's foreign trade is confronted with structural problems such as insufficient development of import trade, unbalanced development of foreign trade in various cities, uncoordinated development of service trade and goods trade, and irrational main structure of foreign trade. It is necessary to speed up the implementation of supply-side structural reform, establish the new concept of "great opening", construct the new mode of "great foreign trade", take the new step of "great development", and accelerate the construction of modern foreign trade system in Anhui Province.