Abstract: To implement innovation and entrepreneurship education, it is necessary to strengthen the training of innovative thinking and cultivate students' creativity in fostering professional quality; To cultivate students' entrepreneurship ability, the teaching of mechatronics technology application course should be reformed and C5W mode should be adopted in teaching, so as to strengthen students' marketing ability, management ability, especially professional and technical ability; In addition, an innovative entrepreneurship support system should be built in time to effectively improve the success rate of students' innovation and entrepreneurship.