Abstract: There are some shortcomings in ideological and political teaching in colleges and universities, such as the excavation of textbooks' connotation, the activation of teachers' enthusiasm, and the combination of theory and practice. The "guidance and inquiry" teaching method can effectively improve teaching effect by arranging teaching links reasonably, integrating teaching elements, thread teaching processes together, firmly hold the three elements of teachers, students and classes, and insist on the guidance of teachers and the inquiry of students in the teaching process.