Abstract: The development of information technology represented by mobile Internet provides a new mode and thinking for ideological and political work in colleges and universities. Colleges and universities should be guided by students' needs for success, make full use of the convenience, equality and interaction of new media, and actively carry out micro ideological and political work. The development of micro ideological and political education is extremely unbalanced among different colleges and universities, different departments of colleges and universities and different subjects of ideological and political work team. Therefore, only by establishing "micro concept", creating "micro matrix", building "micro team", innovating "micro products", and constantly exploring the mode of "micro ideological and political work" in colleges and universities in practice, can we do a good job in ideological and political work under the condition of mobile Internet.