Abstract: It is an inevitable requirement for the development of the times to cultivate innovative and entrepreneurial talents with innovative consciousness, spirit, thinking and ability. Ideological and political theory course is the main channel of ideological and political work of students in colleges and universities, which plays an important role in ideological guidance, value guidance and method guidance in innovation and entrepreneurship education. Colleges and universities should give full play to the role of ideological and political theory course, strive to make them work together with innovation and entrepreneurship education, and help college students become successful entrepreneurs.