Abstract: Based on the development characteristics of the Yangtze River economic belt and the basic connotation of high-quality development, this paper selects 28 indicators from five dimensions of green development, economic quality, innovation ability, people's life and open cooperation to build an index system for measuring and evaluating the high-quality development of the Yangtze River economic belt, and studies the developmentalequilibrium problem of high-quality regions in the Yangtze River economic belt with panel data from 2008 to 2017 as samples. The results show that:the high-quality development of the Yangtze River economic belt is in a steady state of improvement, but there are problems in the process of development, such as the imbalance of regional development; the coupling coordination degree is in an overall growth trend, but the growth range is not large, the whole is in the transition range of coupling coordination, and there are provincial differences.