Abstract: As China's poverty alleviation has entered the final stage, rural economic development and farmers' income increase in poor areas have gradually become the target of targeted poverty alleviation. This paper analyzes the practical needs and feasibility of e-commerce to help farmers. Taking the poverty alleviation and agricultural assistance project of Anhui University of Technology in Hongshiyan village, Yu'an District, Lu'an City as an example, this paper explores a new mode of organic combination of education and industry to help farmers. Under the innovative mode of e-commerce to help farmers, farmers, consumers, e-commerce platform and village collective economy can achieve a win-win situation.