Abstract: Anhui economic development requires that safety engineering talents should have strong adaptability and high comprehensive quality. The safety engineering specialty in colleges and universities has the characteristics of comprehensiveness, practicality and variability. It is necessary to update the teaching content in time, enhance student' interest in learning through interactive teaching, promote students' ability by case teaching, and guide students to participate in teachers' scientific research projects to cultivate students' innovative spirits, so as to cultivate high-quality safety engineering talents for local economic development.