Abstract: Enterprise college is an effective implementation platform for implementing the talent cultivation of modern apprenticeship with a combination of work and study. Its operation process needs to integrate the core interest demands of various core stakeholders. In cooperation, all parties need to carefully select the specialties of pilot colleges and cooperative enterprises, scientifically allocate complementary resources of all parties, and reasonably set ladder talent training objectives based on the incentive compatibility theory. On this basis, a good incentive compatible operation mechanism of business professional enterprise college is designed, which can effectively promote the operation of enterprise college in colleges and universities.