Abstract: Based on the background of the integrated development of the Yangtze River Delta, this paper analyzes the current situation of the higher education structure in Anhui. The study finds that the regional and provincial layout, level types, disciplines and specialties of higher education in Anhui Province are in a backward position in the Yangtze River Delta region to varying degrees. In order to improve the level of regional development of Anhui higher education services, it is necessary to adhere to the strategic orientation of regional integrated development. The balance, coordination and adequacy of Anhui higher education development, systematically optimize the structure of Anhui's higher education.