Abstract: In order to adapt to the construction of new engineering, medical information engineering needs to promote the integration of disciplines and cultivate more high-quality interdisciplinary talents. By strengthening the top-level design to reconstruct the talent training program, implementing the medical and educational integration to reset the curriculum teaching system, strengthening the school-enterprise cooperation and innovation practice teaching mechanism, strengthening and optimizing the teaching staff, and improving the course evaluation method, the quality of professional talent training is effectively improved.