Abstract: Based on the new era, the innovation and entrepreneurship education in colleges and universities is faced with the inevitable requirements of the deepening and improvement of the system, upgrading and development. To summarize, analyze and reflect on the current situation of the innovation and entrepreneurship education reform in colleges and universities such as achievements and shortcomings is the premise and basis of continuing to deepen the reform. It is the future path to gradually improve the deepeningof reform of innovation and entrepreneurship education in colleges and universities to strengthen the main responsibility of administrators in running schools, strengthen the leading role of teachers in teaching, lead students to study consciously, improve the cooperative mechanism of society to promote learning, and build a new pattern of "four learning in one" education.