Abstract: Hefei metropolitan areas and Nanjing metropolitan areas both belong to the Yangtze River Delta economic zone, which are respectively cultivated and mature metropolitan areas. Based on the principal component analysis method, the index data of 12 prefecture-level cities in the two metropolitan areas in 2012, 2015 and 2018 are selected to build a comprehensive competitiveness evaluation system and conduct a time series analysis of the comprehensive competitiveness of the two metropolitan areas. The results show that the comprehensive competitiveness of Hefei metropolitan area has been significantly improved in recent years, but there is still a big gap in economic development, science and education strength and infrastructure construction compared with Nanjing metropolitan area. In addition, the promotion of industrial cooperation between the two metropolitan areas, the acceleration of the construction of rail transit, the strengthening of scientific and technological innovation, the introduction of new talents,the acceleration of the interconnection of infrastructure between the central city and surrounding areas and the sharing of public services resources will be conducive to promoting the integrated and coordinated development of Hefei and Nanjing metropolitan areas.