Abstract: As a basic professional course, there are some problems in physical chemistry D, such as strong theoretical content, great difficulty and lack of students’ interest in learning. In teaching practice, attention should be paid to implementcurriculum ideological and political education, cultivate students’ patriotism and professional confidence, create smart classrooms to guide students to learn independently, increase teaching cases to improve students’ ability, and stimulate students’ interest in scientific research and cultivate their innovation ability. With a series of reforms, good results have been achieved in curriculum teaching.