Abstract: As a platform for collaborative development in the field of education, the Yangtze River Delta (YRD) Regional University Consortium is of great significance in promoting scientific and technological innovation and industrial development in the YRD region, as well as in creating a model area for talent cultivation in the new era. However, in the process of development, the university consortium is caught in the dilemma of “union but not alliance” and “alliance but not excellent”. In view of this, we put forward specific suggestions to promote the development of university alliances in the Yangtze River Delta region: rationally selecting alliance members and optimizing the structure of alliance members; breaking the limitations of university boundaries and promoting in-depth cooperation among alliance members; establishing an operation and management platform and forming a standardized management system; and improving the framework of interaction and realizing the unity of the double constraint function.