Abstract: The development of innovation and entrepreneurship education empowering disciplines and specialties in local undergraduate universities needs to clarify its connotation from the development level of the country, universities, and specialties themselves, seek logical integration from talent cultivation, collaborative symbiosis, and fundamental tasks realization, and achieve closed-loop integration from aspects such as goalachievements, resource platforms, practical teaching, and cooperation models. The integration of the two should not only ensure that innovation and entrepreneurship education takes root, but also focus on the implementation of measures to empower the development of disciplines and specialties.