Abstract: The second classroom serves as a crucial extension of the first classroom and represents a pivotal lever and effective avenue for promoting innovation and entrepreneurship education among university students. Aligning the model of cultivating individuals through the second classroom transcript with the objectives of higher education in fostering innovative talents, this study advocates the integration of university-level innovation talent development with the second classroom transcript. By consolidating both internal and external resources, optimizing second classroom teaching, and transforming it into an innovative practical education platform in service of the first classroom, the aim is to fully exploit the role of the “second classroom transcript” system in cultivating innovation-oriented talents within higher education.