Abstract: Under the background of emerging engineering education, the teaching reform of courses is the important way of training high quality scientific and technological talents. In view of the current teaching process of Synthesis and Application of Surfactants course, there are problems such as strong cross-cutting teaching content, low motivation of students to learn, and poor combination of theory and practice, etc. Combined with the characteristics of the course, we have integrated craftsmanship into the teaching of the course by improving the syllabus, updating and optimizing the teaching content, and implementing diversified teaching modes, etc., so as to improve the quality of teaching and effect of educating human beings.