Abstract: The regional culture is the crystallization of the unique humanistic spirit and historical wisdom of different places. We should incorporate it into the ideological and political education system, learn the value essence contained therein, optimize the discourse expression of ideological and political lessons, and then improve the effectiveness of teaching practice. In view of the current prominent problems such as narrow development area of regional cultural resources, not deep connotation mining and single integration form, we should start from the top level of system design, find the meeting point, continue to make efforts in the consolidation of intensity, connotation refining, teaching methods and teachers, strengthen the effective allocation of regional cultural resources in ideological and political education of college students, and improve the effect of collaborative education.