Abstract: The development of internationalization of local high-level universities in Anhui province is not only an important part of the new course in the new field of our country’s higher education development, but also the meaning of deeply integrating into the national open-up enrollment policy. Since entering the new era, the international cooperation and exchange work of high-level local universities in Anhui province has made remarkable achievements, but there are still many problems, such as the advanced internationalization concept has not been implemented, the effective cross-cultural mechanism has not been formed, the internationalization level of teachers needs to be improved, the internationalization mode and content need to be upgraded, and the Sino-foreign cooperation in running schools needs to be deepened. In view of this, the development of internationalization of local high-level universities in Anhui province should take the concept as the guidance, let the internationalization policy take root; take the personnel exchange as the core to carry out the internationalization comprehensively; take the curriculum as the basis to promote the internationalization of higher education at home; take scientific research as the important point, to explore the characteristics of internationalization; and through cooperation to promote regional internationalization.