Abstract: In order to improve the popularity of regional red culture, this paper puts forward the process and method of regional red cultural and creative design based on semiotics. This paper interprets Anqing regional red culture from three dimensions of semantics, pragmatics and structure, and constructs a design and translation model of Anqing regional red cultural and creative products based on semiotics. Firstly, the relationship between explicit and recessive in Anqing regional red cultural resources is sorted out from the semantic dimension. Secondly, from the pragmatic dimension, DEMATEL model is used to complete the screening of red cultural resources, and the design symbols are refined according to the needs of users. Finally, from the linguistic dimension, the design method of overall deconstruction + local reconstruction is applied to complete the design practice, and the design process of "interpretation of cultural symbols", "extraction of cultural symbols" and "translation of cultural symbols" is realized. Taking the design of Anqing regional red cultural and creative products as an example, through the interpretation of Anqing red objects, red buildings and other elements, the regional red culture and innovation practice was carried out to verify the feasibility of the design process of red cultural and creative products, and to provide ideas for the design and development of regional red cultural and creative products.