Abstract: The course serves as the fundamental unit and core element in talent cultivation. For the cultivation of high-quality talents, the construction of high-quality courses is pivotal. Taking the national first-class undergraduate construction course of “Inorganic Chemistry” as an opportunity, Anhui University of Technology has deeply apprehended the connotation of course construction, strengthened the top-level design of course construction, based on the cultivation of students’ knowledge, ability and quality. With the construction of ideological and political education in courses as the main thread, problem-oriented, and the construction of course content as the emphasis, and the construction of the teaching staff as the key point, it has promoted the overall reform of teaching organization mode, teaching methods, teaching resources and teaching evaluation in a coordinated manner, and effectively advanced the high-quality construction of the “Inorganic Chemistry” course and attained excellent achievements.