Abstract: Chemical Thermodynamics is one of the core courses in chemical engineering. Due to the abstract concepts, many theoretical formulas, and strong applicability, a series of problems have arisen, such as low learning motivation, and insufficient theoretical transformation ability. In order to meet the requirements for new innovative talents in chemical engineering in the context of the construction of new engineering disciplines, optimizing the teaching content, strengthening innovative training and engineering practice, introducing course ideology, and conducting diversified assessment can cultivate students’ innovative thinking and engineering awareness and improve the teaching quality of the course.