Abstract: Excellent regional culture is highly consistent with university ideological and political education in terms of spiritual connotation and educational goals, and the integration of the two can solve the homogenization dilemma of ideological and political education. In practice, the integration of excellent regional culture into university ideological and political education faces multiple dilemmas in resource adaptation, educational coherence, subject collaboration, institutional guarantee, and efficacy evaluation. Accordingly, it is necessary to strengthen the collaboration of educational subjects, deepen the transformation of cultural resources and educational contents, innovate the integration of immersive education, and improve the institutional guarantee system, so as to realize the long-term and effective integrated development of cultural education and ideological and political education.