Abstract: Taking urban agglomeration in the middle reaches of the Yangtze River as the foundation, absorbing and radiating the surrounding key tourism areas, especially the south Anhui international cultural tourism demonstration area, and then forming a tourist area in the middle reaches of the Yangtze River are of great significance to the national economic and social development. The tourism competition and cooperation between urban agglomeration in the middle reaches of the Yangtze River and south Anhui international cultural tourism demonstration area should focus on the regional integration planning and construction, the product integration brand building, and the coupling system connection with the regional strategic development. This coupling mechanism is manifested as integration coupling with regional development, cultural creativity coupling, tourism and recreation integration coupling and so on.