Abstract: Pharmaceutical equipment and technological design is a practical course in the pharmaceutical engineering specialty. Aiming at the existing problems in the traditional teaching mode, the teaching mode of pharmaceutical equipment and technological design was explored from three aspects of cognition and production practice, theoretical teaching and graduation design. Based on the mode of practice-theory-practice, it made students realize from perceptual knowledge to rational knowledge and up to practice, achieving the organic integration of theory and practice, and the goal of cultivating the talents with innovation and practical ability.