Abstract: The importance of practical teaching of ideological and political theory course in colleges and universities has been generally recognized by the academic circles, but there are divergent views on its connotation. And the limitation of the researches on teaching mode, problems and countermeasures in guiding practical teaching are becoming increasingly prominent. In accordance with the requirements of teaching objectives, the practical teaching of ideological and political theory course should find out diversified implementation approaches in the contradictory relationship between the subject and the object of education based on methodological principles from the perspective of methodology. The choices of methods or modes are restricted by the external environment, so it is necessary to fully consider the role of external factors such as social environment, educational technology means, space-time conditions and so on.