Abstract: The curriculum system of innovation and entrepreneurship education course for economics majors is lack of systematization, and there are deficiencies in the content of teaching materials, teaching methods and teaching staff. Therefore, colleges and universities should build a progressive curriculum system of innovation and entrepreneurship education for economics majors, which is composed of general courses, professional courses and practical courses, and provide guarantee from teaching resources, practice platform, teaching staff, curriculum evaluation and financial support, so as to improve the quality of talent training.