Abstract: Based on the theoretical analysis of artificial intelligence for manufacturing upgrading, the panel data of Anhui Province from 2010-2019 were selected to empirically analyze the impact of artificial intelligence on manufacturing upgrading in Anhui. The results demonstrate that AI has a significant positive impact on manufacturing upgrading in Anhui, and foreign trade and government participation also play an important role in manufacturing upgrading in Anhui, but foreign direct investment, innovation ability, and human capital level can hardly promote manufacturing upgrading and even have an inhibitory effect in Anhui.