Abstract: The course of Learning and Application of English Vocabulary is a provincial demonstration course under the SPOC teaching mode. As a result of large-class teaching, the curriculum designs and implements diverse interactive links guided by the multi-dimensional interactive strategy with the study group as the basic unit of activity. Through the establishment of multiple online and offline interactive platforms, various teacher-student and student-student interactions are arranged in an all-round way before, during, and after class. Among them, strategic rational interaction focuses on rich content in various forms, and communicative rational interaction focuses on communication and timely follow-up. Multi-dimensional interactions under the SPOC teaching mode complement each other to promote the teaching quality of the course.