Abstract: Under the background of engineering education certification, by analyzing the graduation requirements of engineering education certification for engineering students, this paper puts forward five measures, including focusing on mathematics thought and method, adjusting teaching content, changing teaching mode, reforming assessment and evaluation system and improving teachers’ engineering background knowledge, to explore and practice the teaching reform of mathematics course in engineering major universities. These five measures play a certain role in improving the teaching effect and cultivating students’ innovation ability and problem-solving ability.