Abstract: The teaching process of C programming adopts the organic combination of "online and offline hybrid teaching" and "integrated teaching of theory and practice" to explore the construction of "national first-class courses". In the construction of curriculum resources, we emphasize the cultivation of programming thinking ability and the ability to solve complex projects, in the practical teaching, we adopt the combination of remote virtual simulation experiments and on-site operation in the machine room, and in the teaching evaluation, we pay attention to the process assessment.